Fantasy football owners face tough start 'em, sit 'em questions right away in Week 5 with a potential battle of backup RBs in the Colts-Broncos Thursday night showdown, and things don't get much easier heading into the weekend. Fortunately, Sporting News NFL writer Vinnie Iyer is here to help with his Week 5 fantasy lineup advice and DFS tips.Usage/production trends and a new set of favorable/unfavorable matchups affect lineup decisions every week, but the biggest i sue will always be injuries. There are plenty of big ones set to affect Week 5 Bruce Brown Jr. Jersey lineups, starting with Javonte Williams' season-ending ACL tear and Jonathan Taylor's worrisome ankle i sue. Beyond those, Keenan Allen (hamstring), Alvin Kamara (ribs), D'Andre Swift (shoulder), David Montgomery (knee, ankle), Michael Thomas (toe), Amon-Ra St. Brown (ankle), Jakobi Meyers (knee), Hunter Renfrow (concu sion), Daniel Jones (ankle), and Jameis Winston (back) are all dealing with ailments that could keep them out, and you know more injuries will pop up later in the week. That's on top of players like Cordarrelle Patterson (knee), Treylon Burks (toe), Jahan Dotson (hamstring), and Tua Tagovailoa (head) who have already been ruled out.Throw in the potential returns of players who started the season on IR (Brian Robinson Jr., Gus Edwards) and yet another early-morning London game (Packers-Giants), and fantasy owners will need to be "on call" all weekend.Navigating through a wide array of potential starting options, here are our must-starts and start 'em sit 'em recommendations for Week 5. If you have specific lineup questions, check out RotoBaller's industry-leading "Who To Start?" tool below and compare up to four players acro s all positions.MORE: and receive exclusive acce s to their premium lineup tools, DFS cheat sheets, and Team Sync platform! .WEEK 5 FANTASY PICKS: | QB must-startsJosh Allen, Bills (vs. PIT)Patrick Mahomes, Chiefs (vs. LV)Jalen Hurts, Eagles (at ARI)Lamar Jackson, Ravens (vs. CIN)Joe Burrow, Bengals (at BAL)Justin Herbert, Chargers (at CLE)Kyler Murray, Cardinals (vs. PHI) Spencer Dinwiddie Jersey Stronger starts Tom Brady, Buccaneers (vs. ATL). He has his groove back (at least on the field), and he'll shred a weak overall defense at home.Derek Carr, Raiders (at KC). He is bound to put up plenty of garbage pa sing points opposite Patrick Mahomes.Kirk Cousins, Vikings (vs. CHI). He will be solid given it's back to being an afternoon home game vs. an average defense.Aaron Rodgers, Packers (vs. NYG in London). He won't need to do a ton, but the Giants' secondary stinks, so 250 yards and two TDs are easy pickings.Carson Wentz, Commanders (vs. TEN). He likes to rip into weaker defenses, and this is a sneaky shootout.Trevor Lawrence, Jaguars (vs. HOU). Lawrence will rock it again in a comfortable spot against a defense that cannot stop the run or pa s.Ryan Tannehill, Titans (at WAS). Plenty is being given up by this atrocious Commanders pa s defense.DFS TargetsFanDuel cash game pickTom Brady, Buccaneers ($7,800 vs. ATL). The GOAT unleashed fury late against the Chiefs, and he will take out some i sues on the Falcons' wilting defense with at least 300 yards and three TD.DraftKings tournament pickAndy Dalton (if he starts, $5,200 vs. SEA). Dalton would be the cheapest veteran QB on the board not named Davis Mills or Baker Mayfield if he starts again for Jameis Winston. He won't go full Jared Goff at home on the Seahawks' defense, but he can get a 3X or 4X value.Streamer SpecialTeddy Bridgewater, Dolphins (at NYJ). This is a sweet "revenge" game Garrett Temple Jersey spot where he can ride his wide receivers to Tua-like production in a great matchup.WEEK 5 PPR RANKINGS: | | | | | Weaker startsMatthew Stafford, Rams (vs. DAL). He's borderline droppable when he's not producing TDs and racking up turnovers.Jared Goff, Lions (at NE). Bill Belichick will find a way to fluster him, too.Geno Smith, Seahawks (at NO). Smith struggled against the one tricky defense on the road he faced, so don't expect follow-up big numbers here, either.Jimmy Garoppolo, 49ers (at CAR). It will be hard for Jimmy G to post big numbers when it will be so easy for the 49ers to run.Zach Wilson, Jets (vs. MIA). He has some youthful upside, but don't force it.Kenny Pickett, Steelers (at BUF). He also has some youthful upside, but don't force it.Justin Fields, Bears (at MIN). He still has some youthful upside, but don't force it.WEEK 5 STANDARD RANKINGS: | | | | | RB must-startsNick Chubb, Browns (vs. LAC)Saquon Barkley, Giants (at GB in London)Austin Ekeler, Chargers (at CLE)Derrick Henry, Titans (at WAS)Christian McCaffrey, Panthers (vs. SF)Aaron Jones, Packers (vs. NYG in London)Joe Mixon, Bengals (at BAL)James Robinson, Jaguars (vs. HOU)Clyde Edwards-Helaire, Chiefs (vs. LV)Jamaal Williams, Lions (at NE)Dameon Pierce, Texans (at JAX)Leonard Fournette, Buccaneers (vs. ATL)Jeff Wilson Jr., 49ers (at CAR)Josh Jacobs, Raiders (at KC)Dalvin Cook, Vikings (vs. CHI)Najee Harris, Steelers (at BUF)AJ Dillon Jeff Green Jersey , Packers (vs. NYG in London)Miles Sanders, Eagles (at ARI)Khalil Herbert, Bears (at MIN)James Conner, Cardinals (vs. PHI)Stronger starts JK Dobbins, Ravens (vs. CIN). He's getting the key volume now as the clear lead back, and the Ravens should lean run heavier here.Alvin Kamara or Mark Ingram, Saints (vs. SEA). Whoever runs the ball against the Seahawks needs to be in lineups.Damien Harris and Rhamondre Stevenson, Patriots (vs. DET). They won't be hiding the fact they will ride the running game hard again in this cake matchup.Breece Hall, Jets (vs. MIA). He's trending toward feature volume with the Jets trending toward fully embracing the rookie's talent.Kareem Hunt, Browns (vs. LAC). The Browns should be run-heavy to attack the clear Chargers' weakne s.Raheem Mostert, Dolphins (at NYJ). They should stay more grounded, and his effective volume should add up to a TD this week.Travis Etienne, Jaguars (vs. HOU). He should get plenty of receiving and rushing work in support of James Robinson.DFS targetsFanDuel cash game picksAustin Ekeler, Chargers ($9,000 at CLE). Check on the status of Myles Garrett (shoulder), but if the Browns' defensive line is depleted again Ekeler can stay white hot.Damien Harris, Patriots ($7,200 vs. DET). Harris was an absolute hammer against the Packers and can bring it even more against the Lions (see Rashaad Penny).DraftKings tournament DeAndre Jordan Jersey picksRhamondre Stevenson, Patriots ($5,500 vs. DET). Stevenson has similar u